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1124-11-4 - 2,3,5,6-Tetramethylpyrazine, 98+% - A18279 - Alfa Aesar

A18279 2,3,5,6-Tetramethylpyrazine, 98+%

Numéro CAS
1124-11-4
Synonymes

Dimensions Prix ($) Quantité Disponibilité
25g 38,70
100g 127,00
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2,3,5,6-Tetramethylpyrazine, 98+%

MDL
MFCD00006146
EINECS
214-391-2

Propriétés chimiques

Formule
C8H12N2
Poids formulaire
136.20
Point de fusion
83-86°
Point d'ébullition
190°
Densité
1.08
Solubilité
Soluble in water (4 g/L at 20°C).

Applications

2,3,5,6-Tetramethylpyrazine is an anti-inflammatory compound isolated from the fermented food natto. It demonstrated in vivo nootropic activity in rats. It is useful in the treatment of several disorders such as asthma, heart failure, rhinitis and urinary incontinence. It is a flavor ingredient of tobacco. It forms cocrystal with 4-hydroxybenzoic acid which exhibits supramolecular synthon polymorphism.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Références bibliographiques

B.R.Sreekanth; Peddy Vishweshwar; K.Vyas. Supramolecular synthon polymorphism in 2 : 1 co-crystal of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine. Chemical Communications. 2007, 23,2375-2377.

 

Wei Wu; Xiao Yu; Xiao-Ping Luo; Shu-Hua Yang; Dong Zheng. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behavioural Brain Research. 2013, 253,212-216.

Has been used as a component of a buffer to control the acid-catalyzed ring-opening of epoxides: J. Chem. Soc., Perkin 2, 1309 (1972).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
113100
Code tarifaire harmonisé
2933.99
TSCA
Yes
RTECS
UQ3905000

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Catalyseurs

Analytique et matériel de laboratoire