Convenient trifluoromethylating agent. In combination with CuI, KF and DMF, trifluoromethylation of aryl and vinyl halides is achieved via the generation of trifluoromethylcopper: Tetrahedron Lett., 32, 7689 (1991); J. Fluorine Chem., 55, 225 (1992). Similarly, nitroaryl chlorides undergo substitution to give the trifluoromethyl derivatives in high yield: J. Fluorine Chem., 66, 167 (1994)./n
Mentions de danger (UE): H225-H314-H318
Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.
Mentions de prudence: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.