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75-80-9 - 2,2,2-Tribromoethanol, 99% - 2,2,2-Tribromoethyl alcohol - A18706 - Alfa Aesar

A18706 2,2,2-Tribromoethanol, 99%

Numéro CAS
75-80-9
Synonymes
2,2,2-Tribromoethyl alcohol

Dimensions Prix ($) Quantité Disponibilité
5g 26,50
25g 77,20
100g 233,00
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2,2,2-Tribromoethanol, 99%

MDL
MFCD00004671
EINECS
200-903-1

Propriétés chimiques

Formule
Br3CCH2OH
Poids formulaire
282.76
Point de fusion
77-80°
Point d'ébullition
92-93°/10mm
Sensibilité
Light Sensitive
Solubilité
Soluble in alcohol, ether, benzene and warmpetroleum ether. Partially soluble in water.

Applications

2,2,2-Tribromoethanol is utilized in organic synthesis of beta-amino alcohols. The pharmaceutical preparation of tribromoethanol serves as an anesthetic in medicine.

Notes

Light Sensitive. Store in cool and well ventilated area. Keep container tightly closed.

Références bibliographiques

Carboxyl groups can be protected as tribromoethyl esters, e.g. by reaction of the acid chloride in the presence of N,N-dimethylaniline. The group is readily cleaved with Zn/AcOH: J. Chem. Soc., Pekin 1., 2875 (1993); (cf. 2,2,2-Trichloroethanol, L08163). The group has also been exploited in the activation of carboxylic acids for amidation with amines, by reductive cleavage of the tribromoethyl ester with a P(III) reagent, preferably Hexamethyl­phosphorous triamide, A12571, and triethylamine. In an analogous esterification method with alcohols, tributylphosphine - DMAP was the preferred system: J. Org. Chem., 64, 1430 (1999).

Maheras, K. J.; Gow, A. Increased anesthesia time using 2,2,2-tribromoethanol-chloral hydrate with low impact on mouse psychoacoustics. 2013, 219 (1), 61-69.

Jong, W. M. C.; Zuurbier, C. J.; Winter, R. J.; Van den Heuvel, D. A. F.; Reitsma, P. H.; Cate, H. T.; Ince, C. Fentanyl-fluanisone-midazolam Combination Results in More Stable Hemodynamics than does Urethane-α-chloralose and 2,2,2-tribromoethanol in Mice. 2002, 41 (3), 28-32.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
1733249
Code tarifaire harmonisé
2905.59
TSCA
Yes
RTECS
KM3675000

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