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1118-68-9 - N,N-Dimethylglycine, 98+% - Dimethylaminoacetic acid - A19670 - Alfa Aesar

A19670 N,N-Dimethylglycine, 98+%

Numéro CAS
1118-68-9
Synonymes
Dimethylaminoacetic acid

Dimensions Prix ($) Quantité Disponibilité
5g 54,38
25g 202,91
100g 572,40
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N,N-Dimethylglycine, 98+%

MDL
MFCD00004283
EINECS
214-267-8

Propriétés chimiques

Formule
C4H9NO2
Poids formulaire
103.12
Point de fusion
179-183°
Sensibilité
Hygroscopic
Solubilité
Soluble in water.

Applications

N,N-Dimethylglycine is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of protein degradation in chronic obstructive lung disease (COPD) patients. Further, it is used as a substrate to identify, differentiate and characterize amino acid methyltransferase. It plays an important role for the development of glycine-based ionic liquids and emulsifiers.

Notes

Hygroscopic. Incompatible with strong oxidizing agents.

Références bibliographiques

Additive which promotes the Heck coupling reaction of unactivated aryl chlorides with alkenes, catalyzed by Pd(II) in the presence of Tetraphenyl­phosphonium chloride, A10575: Angew. Chem. Int. Ed., 37, 481 (1998). The combination with Bis(benzonitrile)dichloropalladum constitutes a highly active phosphine-free catalyst system for Heck reactions of aryl bromides: Tetrahedron Lett., 39, 8449 (1998); see also: Tetrahedron Lett., 39, 8449 (1998). Promotes the copper(I)-catalyzed Ullmann-type coupling of aryl bromides and iodides with amines: Org. Lett., 5, 2453 (2003), and phenols: Org. Lett., 5, 3799 (2003), to give substituted anilines and diaryl ethers, respectively. Aryl iodides can also be coupled with aliphatic alcohols to give aryl alkyl ethers: Synlett, 243 (2007). In combinatiion with CuI, vinyl halides with phenols give aryl vinyl ethers: Synlett, 1767 (2005).

McEntyre, C. J.; Lever, M.; Chambers, S. T.; George, P. M.; Slow, S.; Elmslie, J. L.; Florkowski, C. M.; Lunt, H.; Krebs, J. D. Variation of betaine, N,N-dimethylglycine, choline, glycerophosphorylcholine, taurine and trimethylamine-N-oxide in the plasma and urine of overweight people with type 2 diabetes over a two-year period. Ann. Clin. Biochem. 2015, 52 (3), 352-360.

Kapustin, E. A.; Minkov, V. S.; Stare, J.; Boldyreva, E. V. One Hydrogen Bond-Two Ways To Build a Structure. The Role of N-H···O Hydrogen Bonds in Crystal Structures of N,N-Dimethylglycine. Cryst. Growth Des. 2014, 14 (4), 1851-1864.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H302

Harmful if swallowed.

Mentions de prudence: P264-P270-P301+P312-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,3244
Code tarifaire harmonisé
2922.49
TSCA
Yes
RTECS
MB9865000

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