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75-05-8 - Acetonitrile, 99% - Methyl cyanide - Cyanomethane - A19862 - Alfa Aesar

A19862 Acetonitrile, 99%

Numéro CAS
Methyl cyanide

Dimensions Prix ($) Quantité Disponibilité
500ml 30,10
2500ml 89,20
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Acetonitrile, 99%


Propriétés chimiques

Poids formulaire
Point de fusion
Point d'ébullition
Point d'éclair
Indice de réfraction
Miscible with water, alcohols, ethers, acetone, chloroform, carbon tetrachloride and ethylene chloride. Immiscible with saturated hydrocarbons (petroleum fractions).


Acetonitrile is utilized as a polar aprotic solvent in organic synthesis, and in the purification of butadiene. It is used in all the analytical laboratories as a major component of mobile phase in High Performance Liquid Chromatography (HPLC) and in Liquid Chromatography - Mass Spectrometry (LC-MS). It is used for the extraction of fatty acids, spinning fibers and casting and molding of plastic materials. Aqueous two-phase systems based on acetonitrile and carbohydrates play an important character in the extraction and purification of biomolecules called vanillins. It acts as a stabilizer for the chlorinated solvents, and finds use in the production of DNA oligonucleotides.


Incompatible with alkali metals, acids, bases, reducing agents and oxidizing agents. Highly flammable. Store it away from heat, sparks, and flame exposure.

Références bibliographiques

Polar aprotic solvent for a wide variety of reactions, including nucleophilic substitutions, oxidations, reductions and organometallic reactions. Widely used with crown ethers for the generation of 'naked' anions from their salts; see, e.g. 18-Crown-6, A11249 . Preferred solvent for RuO4 oxidations, due to its coordinating ability; see Ruthenium(III)­ chloride hydrate, 11043 .

Undergoes the Ritter reaction with alcohols or olefins in the presence of acid to give N-substituted acetamides. For benzylic alcohols, modified conditions employing boron trifluoride etherate give high yields: Synth. Commun., 24, 601 (1994). For an example, see 4-Methyl­benzyl­ alcohol, A15315 .

For use in the mild conversion of amides to nitriles, see Benzamide, A10501 .

Cardoso, G. B.; Mourao, T.; Pereira, F. M.; Freire, M. G.; Fricks, A. T.; Soares, C. M. F.; Lima, A. S. Aqueous two-phase systems based on acetonitrile and carbohydrates and their application to the extraction of vanillin. 2013, 104 (5), 106-113.

Xu, K.; Zhu, L.; Zhang, A.; Jiang, G.; Tang, H. A peculiar cyclic voltammetric behavior of polyaniline in acetonitrile and its application in ammonia vapor sensor. 2007, 608 (2), 141-147.

Lam, T. W.; Zhang, H.; Siu, S. K. Reductions of Oxygen, Carbon Dioxide, and Acetonitrile by the Magnesium(II)/Magnesium(I) Couple in Aqueous Media: Theoretical Insights from a Nano-Sized Water Droplet. J. Phys. Chem. A 2015, 119 (12), 2780-2792.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H302-H312-H332-H319

Highly flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes serious eye irritation.

Mentions de prudence: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Classe de danger
Groupe d'emballage
Code tarifaire harmonisé


Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux


Analytique et matériel de laboratoire