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667-27-6 - Ethyl bromodifluoroacetate, 97% - Bromodifluoroacetic acid ethyl ester - B20461 - Alfa Aesar

B20461 Ethyl bromodifluoroacetate, 97%

Numéro CAS
667-27-6
Synonymes
Bromodifluoroacetic acid ethyl ester

Dimensions Prix ($) Quantité Disponibilité
1g 18,55
5g 62,01
25g 190,40
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Ethyl bromodifluoroacetate, 97%

MDL
MFCD00042069
EINECS
211-567-0

Propriétés chimiques

Formule
BrCF2CO2CH2CH3
Poids formulaire
202.99
Point d'ébullition
112-114°
Point d'éclair
21°(69°F)
Densité
1.583
Indice de réfraction
1.3880
Solubilité
Soluble in most organic solvents.

Applications

Ethyl bromodifluoroacetate, is used for the treatment of the Reformat sky reagent with aldehydes and ketones affords 2,2-difluoro-3-hydroxy esters. It is also used in the analysis of reagent purity through IR, NMR.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away from strong oxidizing agents.

Références bibliographiques

S Marcotte.; X Pannecoucke.; C Feasson. Enantioselective Synthesis of α,α-Difluoro-β-amino Acid and 3,3-Difluoroazetidin-2-one via the Reformatsky-Type Reaction of Ethyl Bromodifluoroacetate with Chiral 1,3-Oxazolidines. J. Org. Chem. 199964 ( 23), 8461-8464.

A Sorochinsky.; N Voloshi.; A Markovsky. Convenient Asymmetric Synthesis of β-Substituted α,α-Difluoro-β-amino Acids via Reformatsky Reaction between Davis' N-Sulfinylimines and Ethyl Bromodifluoroacetate. J. Org. Chem. 200368 ( 19), 7448-7454.

Valuable building block for the introduction of the CF2 group by Reformatsky reaction with aldehydes. A further development of this chemistry involves the generation of an ɑɑ-difluoro-ß-lactone, followed by thermal decarboxylation as a high-yield route to 1,1-difluoroalkenes: J. Org. Chem., 60, 5378 (1995):

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Mentions de prudence: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
1906095
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2915.90
TSCA
No

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Analytique et matériel de laboratoire