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17201-43-3 - 4-(Bromomethyl)benzonitrile, 98% - alpha-Bromo-p-tolunitrile - 4-Cyanobenzyl bromide - B20641 - Alfa Aesar

B20641 4-(Bromomethyl)benzonitrile, 98%

Numéro de CAS
17201-43-3
Synonymes
alpha-Bromo-p-tolunitrile
4-Cyanobenzyl bromide

Conditionnement Prix ($) Quantité Disponibilité
5g 45,70
25g 169,00
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4-(Bromomethyl)benzonitrile, 98%

MDL
MFCD00001829
EINECS
241-246-0

Propriétés chimiques

Formule
C8H6BrN
Poids moleculaire
196.05
Point de fusion
113-117°
Solubilité
Soluble in chloroform and methanol. Insoluble in water.

Applications

4-(Bromomethyl)benzonitrile is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.

Notes

Moisture and light sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents, strong acids and bases.

Références bibliographiques

Alcohols can be protected as their 4-cyanobenzyl ethers, e.g. in the presence of NaH. They can be selectively cleaved by electrolytic reduction: Tetrahrdon Lett., 2643 (1979); Chem. Ber., 114, 946 (1981).

Snelling, R.; Saavedra, J. Z.; Bayrasy, P.; Abdollahian, Y.; Singaram, B. Binary reducing agents containing dichloroindium hydride for the selective, partial, or tandem reductions of bifunctional compounds consisting of halo-nitriles, halo-esters and halo-carboxylic acids. Org. Chem. Front. 2015, 2 (2), 133-140.

Bagala, D. B.; Bhanagea, B. M. Recent Advances in Transition Metal-Catalyzed Hydrogenation of Nitriles. Adv. Synth. Catal. 2015, 357 (5), 883-900.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H301-H311-H331-H314-H318-H317

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. May cause an allergic skin reaction.

Mentions de prudence: P260u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a

Do not breathe dusts or mists. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
636717
Classe de danger
8
Groupe d'emballage
II
Code tarifaire harmonisé
2926.90
TSCA
Yes

Recommandé

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  • B24278

    2-(Bromomethyl)benzonitrile, 98%
  • 42588

    Diisobutylaluminum hydride, 25% w/w in hexane

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