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49844-90-8 - 4-Chloro-2-(methylthio)pyrimidine, 98% - 4-Chloro-2-(methylmercapto)pyrimidine - B21481 - Alfa Aesar

B21481 4-Chloro-2-(methylthio)pyrimidine, 98%

Numéro CAS
49844-90-8
Synonymes
4-Chloro-2-(methylmercapto)pyrimidine

Dimensions Prix ($) Quantité Disponibilité
10g 61,80
50g 252,35
250g 990,00
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4-Chloro-2-(methylthio)pyrimidine, 98%

MDL
MFCD00006083
EINECS
256-500-6

Propriétés chimiques

Formule
C5H5ClN2S
Poids formulaire
160.63
Point de fusion
ca -2°
Point d'ébullition
118-120°/9mm
Point d'éclair
>110°(230°F)
Densité
1.380
Indice de réfraction
1.6 00
Sensibilité
Moisture Sensitive
Solubilité
Not miscible or difficult to mix in water.

Applications

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Notes

Moisture sensitive. Store away from oxidizing agents, bases, water/moisture, heat and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated.

Références bibliographiques

Daves GD, et al. Pyrimidines. XIII. 2-and 6-substituted 4-pyrimidinecarboxylic acids.J. Heterocycl. Chem.19641(3), 130-133.

Peter J Manley, et al. 2,4-disubstituted pyrimidines: a novel class of KDR kinase inhibitors.Bioorg. Med. Chem. Lett.200313(10), 1673-1677.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Mentions de prudence: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
118042
Classe de danger
8
Groupe d'emballage
III
Code tarifaire harmonisé
2933.59
TSCA
No

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Analytique et matériel de laboratoire