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178312-62-4 - Homomorpholine hydrochloride, 98% - Hexahydro-1,4-oxazepine hydrochloride - 1,4-Oxazepane hydrochloride - B21749 - Alfa Aesar

B21749 Homomorpholine hydrochloride, 98%

Numéro CAS
178312-62-4
Synonymes
Hexahydro-1,4-oxazepine hydrochloride
1,4-Oxazepane hydrochloride

Dimensions Prix ($) Quantité Disponibilité
1g 249,00
5g 909,00
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Homomorpholine hydrochloride, 98%

MDL
MFCD02683070

Propriétés chimiques

Formule
C5H11NO•HCl
Poids formulaire
137.61
Point de fusion
158-164°
Sensibilité
Hygroscopic
Solubilité
Slightly soluble in water.

Applications

Homomorpholine Hydrochloride is a useful synthetic intermediate. It is used to prepare homomorpholine oxazolidinone with antibacterial activities. It is also used to synthesize A2A adenosine receptor antagonists for the treatment of Parkinson's disease.

Notes

Hygroscopic. Keep away from oxidizing agents, water/moisture. Store under inert atmosphere. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Références bibliographiques

Ji-Young Kim; Frederick E. Boyer; Allison L. Choy; Michael D. Huband; Paul J. Pagano; J.V.N. Vara Prasad. Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents.Bioorganic & Medicinal Chemistry Letters.200919(2), 550-553.

Zhang, X., et al. Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease.J. Med. Chem.200851(22), 7099-7110.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé
2934.99
TSCA
No

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Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire