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67-20-9 - Nitrofurantoin, 98% - N-(5-Nitro-2-furfurylidene)-1-aminohydantoin - B24079 - Alfa Aesar

B24079 Nitrofurantoin, 98%

Numéro CAS
67-20-9
Synonymes
N-(5-Nitro-2-furfurylidene)-1-aminohydantoin

Dimensions Prix ($) Quantité Disponibilité
25g 42,10
100g 120,00
500g 481,00
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Nitrofurantoin, 98%

MDL
MFCD00003224
EINECS
200-646-5

Propriétés chimiques

Formule
C8H6N4O5
Poids formulaire
238.16
Point de fusion
ca 265° dec.
Sensibilité
Light Sensitive & Hygroscopic
Solubilité
Soluble in water (<0.01 g/100 ml at 19°C), dimethyl sulfoxide and methanol.

Applications

Nitrofurantoin is a nitrofuran antibiotic that is used as a substrate of bacterial nitrofuran reductase to study the interactions of active metabolites with DNA, ribosomal proteins and metabolic and pro-oxidant processes. It is an antibactericidal compound that has been historically prepared by the reaction of 1-aminohydantoin sulfate and 5-nitro-2-furaldehyde diacetate. It shows activity against many Gram-positive and Gram-negative bacteria. Nitrofurantoin is effective against enterococci, staphylococci, streptococci, corneybacteria, many strains of Escherichia coli.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Store under dry inert gas. It is hygroscopic in nature. Incompatible with oxidizing agents. It is sensitive to light.

Références bibliographiques

Charles C. McOsker.; Penny M. Fitzpatrick. Nitrofurantoin: Mechanism of action and implications for resistance development in common uropathogens. J. Antimicrob. Chemother. 1994, 33 23-30.

P. R. Hari.; T. Chandy.; C. P. Sharma. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. Journal of Microencapsulation: Micro and Nano Carriers. 1996, 13 (3), 319-329.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H334-H317-H302

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Harmful if swallowed.

Mentions de prudence: P285-P261-P280-P342+P311-P301+P312-P363-P304+P341-P321-P333+P313-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment (see label). If skin irritation or rash occurs: Get medical advice/attention. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé
2934.99
TSCA
Yes
RTECS
MU2800000

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Catalyseurs

Analytique et matériel de laboratoire