It is used for Synthesis of heterocycle compounds and an important intermediate of medicine.
Erick M. Carreira; Wheeseong Lee; Robert A. Singer. Catalytic, Enantioselective Acetone Aldol Additions with 2-Methoxypropene. J. Am. Chem. Soc. 1995, 117 (12), 3649-3650.
D. V. Gorlov; M. A. Kurykin; O. E. Petrova. Acylation of 2-methoxypropene with anhydrides and halides of perfluorocarboxylic acids in the presence of tertiary amines. Russian Chemical Bulletin. 1999, 48 (9), 1791-1792.
Can be used, in the presence of an acid catalyst, for the introduction of the methoxyisopropyl protecting group for alcohols, readily removed under mild acid conditions. Unlike dihydropyran, the resulting acetals do not contain additional chiral centers (i.e. only a single diastereomer results): J. Am. Chem. Soc., 89, 3366 (1967); 94, 7827 (1972); 100, 4616 (1978).
Diols have been protected as their acetonides in the presence of dry HBr in dichloromethane: J. Am. Chem. Soc., 100, 4620 (1978), or TsOH in DMF: J. Chem. Soc., Chem. Commun., 21 (1980), used for selective protection of a 1,3- rather than a 1,2-diol in a sugar.
Mentions de danger (UE): H224-H302
Extremely flammable liquid and vapour. Harmful if swallowed.
Mentions de prudence: P260-P201-P280a-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.