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116-54-1 - Methyl dichloroacetate, 99% - Dichloroacetic acid methyl ester - B24399 - Alfa Aesar

B24399 Methyl dichloroacetate, 99%

Numéro CAS
116-54-1
Synonymes
Dichloroacetic acid methyl ester

Dimensions Prix ($) Quantité Disponibilité
100g 26,82
500g 59,12
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Methyl dichloroacetate, 99%

MDL
MFCD00000843
EINECS
204-146-8

Propriétés chimiques

Formule
C3H4Cl2O2
Poids formulaire
142.97
Point de fusion
-52°
Point d'ébullition
142-144°
Point d'éclair
70°(158°F)
Densité
1.380
Indice de réfraction
1.4420
Solubilité
Soluble in water. (4 g/L).

Applications

Methyl dichloroacetate may be used in the diastereoselctive synthesis of bicyclic chlorocyclopropane, as difunctional initiator during atom transfer radical polymerization of methyl or n-butyl acrylate, as reagent during CrCl2-induced olefination of aldehydes. It is a reactant involved in nucleophilic substitution reactions with nitro(pentafluorosulfanyl)benzenes, azide-alkyl halide cycloaddition and atom transfer radical addition, Chemical modification of STn antigen for enhancement of synthetic carbohydrate vaccines, three component reaction of arynes with cyclic ethers and active methines, catalytic radical haloalkylation for synthesis of neodysidenin and addition reactions for syntehsis of enantiopure 3,4-diamino esters or amides.

Notes

Store at room temperature. Incompatible with oxidizing agents. Ensure proper ventilation.

Références bibliographiques

Ana Escribano.; Concepción Pedregal.; Rosario González.; Alejandro Fernández.; Keith Burton.; Gregory A Stephenson. Diastereoselective cyclopropanation of cyclic enones with methyl dichloroacetate anion. Tetrahedron. 2001, 57 (46),9423-9427 .

Yoshiyuki Mido.; Masao Hashimoto. Conformational isomerism of methyl dichloroacetate. An infrared, Raman and 35Cl NQR study. J. Mol. Struct. 1985, 131 (1-2), 71-81 .

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H332-H315-H319-H335-H227

Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Mentions de prudence: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Classe de danger
6.1
Groupe d'emballage
III
Code tarifaire harmonisé
2915.40
TSCA
Yes
RTECS
AG6625000

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Analytique et matériel de laboratoire