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B25349 Orotic acid, anhydrous, 97%

Numéro de CAS
1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid
Uracil-4-carboxylic acid

Stock No. Conditionnement Prix ($) Quantité Disponibilité
B25349-22 100g 84,40
B25349-36 500g 230,00
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Orotic acid, anhydrous, 97%


Propriétés chimiques

Poids moleculaire
Point de fusion
Storage & Sensitivity
Ambient temperatures.
Slightly soluble in water.


Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5?-phospho-α-d-ribose 1?-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5?-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5?-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.


Stable under recommended storage conditions. Incompatible with oxidizing agents.

Références bibliographiques

Eun-Jeong Jung; Sung-Won Kwon; Byung-Hwa Jung; Seon-Hee Oh; Byung-Hoon Lee. Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. Journal of Lipid Research. 2011, 52,(9), 1617-1625.


Xing Wang; Xiuwen Wang; Mengxin Yin; Zijun Xiao; Cuiqing Ma; Zhixin Lin; Peng George Wang; Ping Xu. Production of uridine 5'-monophosphate by Corynebacterium ammoniagenes ATCC 6872 using a statistically improved biocatalytic process. Applied Microbiology and Biotechnology. 2007, 76,(2), 321-328.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H302-H315-H319

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.

Mentions de prudence: P280a-P305+P351+P338-P301+P312a-P321-P332+P313-P501a

Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé


  • A15398

    Hydroxylamine hydrochloride, 99%
  • L03521

    Cyclobutyl methyl ketone, 97%
  • 47019

    Palladium, 5% on activated carbon powder, Type A109047-5, standard, reduced, nominally 50% water wet

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