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148893-10-1 - O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99% - HATU - 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 1-oxide hexafluorophosphate - H26082 - Alfa Aesar

H26082 O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99%

Numéro CAS
148893-10-1
Synonymes
HATU
1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 1-oxide hexafluorophosphate

Dimensions Prix ($) Quantité Disponibilité
1g 29,46
5g 52,53
25g 138,02
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O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99%

MDL
MFCD00274639

Propriétés chimiques

Formule
C10H15F6N6OP
Poids formulaire
380.23
Point de fusion
ca 185° dec.
Solubilité
Soluble in acetonitrile. Insoluble in water.

Applications

O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate is a coupling reagent and used as an additive in peptide synthesis., It is also involved efficiently to speed up the coupling process and reduces the loss of chiral integrity.

Notes

Moisture sensitive. Incompatible with oxidizing agents and highly acidic or alkaline materials.

Références bibliographiques

Yoshida, M.; Sasahara, K. I.; Doi, T. Total synthesis of cyclodepsipeptide spiruchostatin A on silyl-linked polymer-support. Tetrahedron 2015, 71 (40), 7647-7653.

Xie, Y.; Yu, C.; Li, T.; Tu, S.; Yao, C. An NHC-Catalyzed In Situ Activation Strategy to β-Functionalize Saturated Carboxylic Acid: An Enantioselective Formal [3+ 2] Annulation for Spirocyclic Oxindolo-γ-butyrolactones. Chem. Eur. J. 2015, 21 (14), 5355-5359.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H228-H315-H319-H335-H303

Flammable solid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May be harmful if swallowed.

Mentions de prudence: P210-P261-P280-P240-P241-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Classe de danger
4.1
Groupe d'emballage
II
Code tarifaire harmonisé
2933.99
TSCA
No
RTECS
XZ5633000

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