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196929-78-9 - (R)-(+)-2-Methyl-2-propanesulfinamide, 98% - (R)-(+)-tert-Butyl sulfinamide - H27724 - Alfa Aesar

H27724 (R)-(+)-2-Methyl-2-propanesulfinamide, 98%

Numéro CAS
196929-78-9
Synonymes
(R)-(+)-tert-Butyl sulfinamide

Dimensions Prix ($) Quantité Disponibilité
1g 65,60
5g 222,00
25g 818,00
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(R)-(+)-2-Methyl-2-propanesulfinamide, 98%

MDL
MFCD05861479

Propriétés chimiques

Formule
C4H11NOS
Poids formulaire
121.20
Point de fusion
ca 100-105°
Solubilité
Soluble in chloroform, methanol, tetrahydrofuran, dichloromethane, dimethyl sulfoxide and most organic solvents.

Applications

(R)-(+)-2-Methyl-2-propanesulfinamide is a chiral ligand, which is used in pharmaceutical compositions. Further, it is used in the preparation of beta-chloro sulfinamides in the synthesis of chiral azridines. It is involved in the preparation of organocatalyst for enantioselective reduction of imines. It serves as a reagent for synthesizing chiral amines. In addition to this, it is converted into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones which undergoes iridium-catalyzed asymmetric hydrogenation of olefins.

Notes

Incompatible with strong oxidizing agents, strong acids and bases. Store in a cool place.

Références bibliographiques

Qian, X.; Tang, E.; Fan, J.; Zhu, K.; Zhu, J.; Shabaker, J.; Lo, E.; Malley, M.; Deshpande, R. A stereoselective synthesis of (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl)amino)acetic acid, a highly potent PPAR alpha/gamma dual agonist. Tetrahedron 2015, 71 (50), 9408-9414.

Bender, A. M.; Griggs, N. W.; Anand, J. P.; Traynor, J. R.; Jutkiewicz, E. M.; Mosberg, H. I. Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy mu Opioid Receptor/delta Opioid Receptor Ligands. ACS Chem. Neurosci. 2015, 6 (8), 1428-1435.

Mentions de danger et de prudence du SGH

Mentions de prudence: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé
2930.90
TSCA
No

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