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90347-66-3 - Methyl 3-iodo-4-methylbenzoate, 98% - 3-Iodo-4-methylbenzoic acid methyl ester - H28734 - Alfa Aesar

H28734 Methyl 3-iodo-4-methylbenzoate, 98%

Numéro CAS
90347-66-3
Synonymes
3-Iodo-4-methylbenzoic acid methyl ester

Dimensions Prix ($) Quantité Disponibilité
5g 55,62
25g 125,60
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Methyl 3-iodo-4-methylbenzoate, 98%

MDL
MFCD00230583

Propriétés chimiques

Formule
C9H9IO2
Poids formulaire
276.07
Indice de réfraction
1.5975
Sensibilité
Light Sensitive
Solubilité
Not miscible or difficult to mix with water.

Applications

Methyl 3-Iodo-4-methylbenzoate is used as a reagent in the synthesis of [(pyrazolo[1,5-a]pyridmidinyl)ethynyl]benzamides as selective discoidin domain receptor 1 (DDR1) inhibitors. Also used as a reagent in the preparation of orally bioavailable GZD824 targeting Breakpoint Cluster Region-Abelson (Bcr-Abl) kinase and overcoming antitumor drug resistance.

Notes

Light Sensitive, store in dark. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Références bibliographiques

Gao, M., et al. Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors. J. Med. Chem. 2013, 56(8), 3281-3295.

Ren, X., et al. Identification of GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) Kinase and Overcomes Clinically Acquired Mutation-Induced Resistance against Imatinib.J. Med. Chem. 2013, 56(3), 879-894.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Mentions de prudence: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Autres références

Code tarifaire harmonisé
2916.39
TSCA
No

Recommandé

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Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire