It is used in the design, synthesis and biological evaluation of novel condensed fuoropyrimidines as anti-hyperlipidemic agents. Synthesis of 2-chloromethyl-5-(4- chlorophenyl) thieno [2,3-d]pyrimidin- 4(3H)-one. A stream of dry hydrogen chloride gas was bubbled through an ice-cold mixture of ethyl 2-amino-4-(4-chlorophenyl)thiophene 3- carboxylate.
Henning Lütjens.; Andrea Zickgraf .; Heidi Figler.; Joel Linden.; Ray A. Olsson.; Peter J. Scammells. 2-Amino-3-benzoylthiophene Allosteric Enhancers of A1 Adenosine Agonist Binding:? New 3, 4-, and 5-Modifications. J. Med. Chem. 2003, 46 (10),1870-1877.
Kamaraj Balamurugan.; Subbu Perumal.; Aaramadaka Sunil Kumar Reddy.; Perumal Yogeeswari.; Dharmarajan Sriram. A facile domino protocol for the regioselective synthesis and discovery of novel 2-amino-5-arylthieno-[2,3-b]thiophenes as antimycobacterial agents.Tetrahedron Lett. 2009, 50 (45),6191-6195.
Mentions de danger (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Mentions de prudence: P260-P201-P280g-P304+P340-P405-P501a