2-Chloro-1,3-dimethylimidazolium tetrafluoroborate is a reagent for esterification of C-terminal amino acids to Wang resin without racemization and for coupling α,α-dimethyl amino acids; and for preparation of the benzotriazol-1-yloxy derivative, a new coupling reagent. It is used as a reagent for esterification and peptide coupling of sterically hindered amino acids; preparation of efficient diazo-transfer reagents; oxidative insertion for palladium and nickel catalyst synthesis; and preparation of catalysts for use in coupling reactions.
M.Kitamura; N.Tashiro; S.Miyagawa; T.Okauchi. 2-Azido-1,3-dimethylimidazolinium salts: Efficient diazo-transfer reagents for 1,3-dicarbonyl compounds. Synthesis. 2011, (7), 1037-1044.
Doris Kremzow; Gunter Seidel; Christian W.Lehmann; Alois Furstner. Diaminocarbene- and Fischer-carbene complexes of palladium and nickel by oxidative insertion: preparation, structure, and catalytic activity. Chemistry: A European Journal. 2005, 11,(6), 1833-1853.
Mentions de danger (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a