(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate is used as reagent for synthesis of cyclic RGC pentapeptides for functionalization through click chemistry, fluorescent glucose bioprobes and ReactIR flow cell. It is also used as reagent for disulfide bond engineering, heteroaryl ether synthesis and optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.
Hyang Yeon Lee; Jae Jeong Lee; Jongmin Park; Seung Bum Park. Development of fluorescent glucose bioprobes and their application on real-time and quantitative monitoring of glucose uptake in living cells. Chemistry: A European Journal. 2011, 17, (1),143-150
Markus Muttenthaler; Asa Andersson; Aline D de Araujo; Zoltan Dekan; Richard J.Lewis; Paul F.Alewood. Modulating oxytocin activity and plasma stability by disulfide bond engineering. Journal of medicinal and pharmaceutical chemistry. 2010, 53, (24),8585-8596
Mentions de danger (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.