Consentement d'utilisation des Cookies

J'accepte Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

402-61-9 - 3-Methyl-1H-pyrazole-5-carboxylic acid, 97% - H59899 - Alfa Aesar

H59899 3-Methyl-1H-pyrazole-5-carboxylic acid, 97%

Numéro CAS
402-61-9
Synonymes

Dimensions Prix ($) Quantité Disponibilité
1g 101,66
5g 310,50
Ajouter au panier Ajouter au devis en vrac Afficher l'article

3-Methyl-1H-pyrazole-5-carboxylic acid, 97%

MDL
MFCD00462235

Propriétés chimiques

Formule
C5H6N2O2
Poids formulaire
126.11
Point de fusion
236-240°
Solubilité
Soluble in dimethyl sulfoxide.

Applications

3-Methylpyrazole-5-carboxylic acid is a potent and selective D-amino acid oxidase (DAO) (also known as DAAO, DAMOX and OXDA) inhibitor that protects DAO cells from oxidative stress induced by D-Serine. 3-Methylpyrazole-5-carboxylic acid specifically prevents formalin-induced tonic pain.

Notes

Store at room temperature. Keep away from oxidizing agents.

Références bibliographiques

Donald J. P. Pinto.; Michael J. Orwat.; Shuaige Wang.; John M. Fevig.; Mimi L. Quan.; Eugene Amparo.; Joseph Cacciola.; Karen A. Rossi.; Richard S. Alexander.; Angela M. Smallwood.; Joseph M. Luettgen.; Li Liang.; Bruce J. Aungst.; Matthew R. Wright.; Robert M. Knabb.; Pancras C. Wong.; Ruth R. Wexler.; Patrick Y. S. Lam. Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa1.J. Med. Chem. 2001, 44 (4), 566-578.

James R. Pruitt.; Donald J. P. Pinto.; Robert A. Galemmo, Jr.; Richard S. Alexander.; Karen A. Rossi.; Brian L. Wells.; Spencer Drummond.; Lori L. Bostrom.; Debra Burdick.; Robert Bruckner.; Haiying Chen.; Angela Smallwood.; Pancras C. Wong.; Matthew R. Wright.; Steven Bai.; Joseph M. Luettgen. ;Robert M. Knabb.; Patrick Y. S. Lam.; Ruth R. Wexler. Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor1. J. Med. Chem. 2003, 46 (25),5298-5315 .

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé
2933.19
TSCA
No
RTECS
UQ6407500

Recommandé

  • A12646

    Triethylamine, 99%
  • B23860

    1,3,5-Tribromobenzene, 98%
  • L06731

    1H-Pyrazole-3,5-dicarboxylic acid monohydrate, 98%
  • 87900

    Zinc chloride, anhydrous, 99.95% (metals basis)

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire