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59557-91-4 - 4-Bromo-2-methoxyaniline, 98% - H61454 - Alfa Aesar

H61454 4-Bromo-2-methoxyaniline, 98%

Numéro CAS
59557-91-4
Synonymes

Dimensions Prix ($) Quantité Disponibilité
1g 24,30
5g 109,00
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4-Bromo-2-methoxyaniline, 98%

MDL
MFCD01204266

Propriétés chimiques

Formule
C7H8BrNO
Poids formulaire
202.05
Solubilité
Soluble in methanol.

Applications

4-Bromo-2-methoxyaniline is used as a reagent in the synthesis of 3,5-diamino-1,2,4-triazole ureas as potent anaplastic lymphoma kinase (ALK) inhibitors. It is also used as a reagent in the synthesis of chroman-3-amides as potent Rho kinase inhibitors. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Références bibliographiques

P. S. Portoghese.; H. Nagase.; A. W. Lipkowski.; D. L. Larson.; A. E. Takemori. Binaltorphimine-related bivalent ligands and their .kappa. opioid receptor antagonist selectivity [Erratum to document cited in CA108(17):150771q]. J. Med. Chem. 1988, 31 (10), 2056-2056.

Kate M. Clapham.; Julia Bardos.; M. Raymond V. Finlay.; Bernard T. Golding.; Edward J. Griffen.; Roger J. Griffin.; Ian R. Hardcastle.; Keith A. Menear.; Attilla Ting.; Paul Turner.; Gail L. Young.; Celine Cano. DNA-dependent protein kinase (DNA-PK) inhibitors: Structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (3), 966-970.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H302-H312-H331-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P260u-P201-P280h-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/clothing. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Classe de danger
6.1
Groupe d'emballage
III
Code tarifaire harmonisé
2922.29
TSCA
No

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