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14774-37-9 - 4-(Hydroxymethyl)tetrahydropyran, 98% - 4-Tetrahydropyranmethanol - H64568 - Alfa Aesar

H64568 4-(Hydroxymethyl)tetrahydropyran, 98%

Numéro CAS
14774-37-9
Synonymes
4-Tetrahydropyranmethanol

Dimensions Prix ($) Quantité Disponibilité
250mg 20,00
1g 52,53
5g 210,12
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4-(Hydroxymethyl)tetrahydropyran, 98%

MDL
MFCD00457804

Propriétés chimiques

Formule
C6H12O2
Poids formulaire
116.16
Point d'ébullition
111-115°/15mm
Point d'éclair
61°(142°F)
Indice de réfraction
1.4600
Solubilité
Slightly soluble in water.

Applications

Used as a reagent in the identification and optimization of pteridinone Toll-like receptor 7 agonists, which can be used for the oral treatment of viral hepatitis. 4-(Hydroxymethyl)tetrahydropyran is also a starting material for [1-[(Tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone which is a drug that acts as CB2 cannabinoid receptor agonist.

Notes

Store in cool, dry place in tightly closed container. With adequate ventilation. Store away from oxidizing agent.

Références bibliographiques

Paul A. Roethle; Ryan M. McFadden; Hong Yang; Paul Hrvatin; Hon Hui; Michael Graupe; Brian Gallagher; Jessica Chao; Joseph Hesselgesser; Paul Duatschek; Jim Zheng; Bing Lu; Daniel B. Tumas; Jason Perry; and Randall L. Halcomb. Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis. J. Med. Chem.2013 56(18), 7324-7333.

Jennifer M. Frost; Michael J. Dart; Karin R. Tietje; Tiffany R. Garrison; George K. Grayson; Anthony V. Daza; Odile F. El-Kouhen; Betty B. Yao; Gin C. Hsieh; Madhavi Pai; Chang Z. Zhu; Prasant Chandran; and Michael D. Meyer. Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity. J. Med. Chem.2010 53(1), 295-315.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H318-H315-H335-H227

Causes serious eye damage. Causes skin irritation. May cause respiratory irritation. Combustible liquid.

Mentions de prudence: P210-P261-P280-P305+P351+P338-P304+P340-P310-P362-P312-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
103069
Code tarifaire harmonisé
2932.99
TSCA
No

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