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1535-65-5 - Difluoromethyl phenyl sulfone, 95% - (Difluoromethylsulfonyl)benzene - H64760 - Alfa Aesar

H64760 Difluoromethyl phenyl sulfone, 95%

Numéro CAS
1535-65-5
Synonymes
(Difluoromethylsulfonyl)benzene

Dimensions Prix ($) Quantité Disponibilité
250mg 16,80
1g 64,89
5g 259,56
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Difluoromethyl phenyl sulfone, 95%

MDL
MFCD01050170

Propriétés chimiques

Formule
C7H6F2O2S
Poids formulaire
192.18
Point de fusion
24-25°
Densité
1.324
Indice de réfraction
1.5000
Solubilité
Soluble in chloroform and water.

Applications

Used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls and fluorination. Reagent used for reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes, fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors, difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation. Also used as reagent in preparation of α-difluoromethyl amines via stereo selective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines and Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes.

Notes

Keep container tightly closed. With adequate ventilation. Store away from oxidizing agent.

Références bibliographiques

G K Surya Prakash; Jinbo Hu; George A Olah. Preparation of tri- and difluoromethylsilanes via an unusual magnesium metal-mediated reductive tri- and difluoromethylation of chlorosilanes using tri- and difluoromethyl sulfides, sulfoxides, and sulfones. Journal of Organic Chemistry.2003 68(11), 4457-4463.

Chuanfa Ni; Laijun Zhang; Jinbo Hu. Nucleophilic fluoroalkylation of alpha,beta-enones, arynes, and activated alkynes with fluorinated sulfones: probing the hard/soft nature of fluorinated carbanions. Journal of Organic Chemistry.2008 73(15), 5699-5713.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
2259218
Code tarifaire harmonisé
2930.90
TSCA
No

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