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78111-17-8 - Okadaic acid, 98% - J60155 - Alfa Aesar

J60155 Okadaic acid, 98%

Numéro CAS
78111-17-8
Synonymes

Dimensions Prix ($) Quantité Disponibilité
50microgram 94,10
100microg 167,00
300microg 451,00
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Okadaic acid, 98%

MDL
MFCD00083455

Propriétés chimiques

Formule
C44H68O13
Poids formulaire
805.02
Forme
Powder
Solubilité
It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.

Applications

Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.

Références bibliographiques

Haystead et al. Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature .  1989, 337,(6202), 78-81.

Nuydens et al. Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 1998, 70,(3), 1124-33.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H300-H310-H330-H315

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes skin irritation.

Mentions de prudence: P260-P284-P301+P310-P304+P340-P320-P330-P361-P302+P350-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Remove/Take off immediately all contaminated clothing. IF ON SKIN: Gently wash with plenty of soap and water. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,6819
Classe de danger
6.1
Groupe d'emballage
I
Code tarifaire harmonisé
2932.19
TSCA
No
RTECS
AA8227800

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