A potent, highly selective and reversible inhibitor of the 20S proteasome, Bortezomib is used as an antineoplastic agent, which controls the growth of cancer cells. It is also useful in the treatment of multiple myeloma.
Roelofs, J. Proteasome inhibition by bortezomib: A left hook and a right punch. EBioMedicine 2015, 2 (7), 619-620.
Pantani, L.; Zamagni, E.; Zannetti, B. A.; Pezzi, A.; Tacchetti, P.; Brioli, A.; Mancuso, K.; Perrone, G.; Rocchi, S.; Tosi, P.; Cavo, M. Bortezomib and dexamethasone as salvage therapy in patients with relapsed/refractory multiple myeloma: analysis of long-term clinical outcomes. Ann. Hematol. 2014, 93 (1), 123-128.
Mentions de danger (UE): H300-H310-H330-H372
Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes damage to organs through prolonged or repeated exposure.
Mentions de prudence: P260-P201-P280h-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.