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54965-24-1 - Tamoxifen citrate - cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene citrate - J60955 - Alfa Aesar

J60955 Tamoxifen citrate

Numéro CAS
cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene citrate

Dimensions Prix ($) Quantité Disponibilité
1g 191,00
5g 482,00
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Tamoxifen citrate


Propriétés chimiques

Poids formulaire
White to off-white powder
Light Sensitive & Hygroscopic
Soluble in methanol (50 mg/ml with heat) or ethanol (10 mg/ml with sonication); very slightly soluble in water (0.3 mg/L @ 20°C; the pH is approximately 3.0-3.5), 0.02 N HCl (0.2 mg/ml @ 37°C)4, acetone ,chloroform,and DMSO(100mM)


Tamoxifen citrate is used as an antiestrogen with potent anti-cancer and PKC inhibitory activities. Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.


Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Références bibliographiques

Wakeling et al. Non-steroidal anti-estrogens - receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells. J.Steroid.Biochem. 1984, 20,(1), 111-20.

Paul et al. Both the immunosuppressant SR31747 and the antioestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Δ8-Δ7 sterol isomerase. J.Pharmacol.Exp.Ther. 1998, 285,(3), 1296-302.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H302-H350-H360-H362

Harmful if swallowed. May cause cancer. May damage fertility or the unborn child. May cause harm to breast-fed children.

Mentions de prudence: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé


Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux


Analytique et matériel de laboratoire