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63597-44-4 - 4alpha-Phorbol 12-myristate 13-acetate, 99% - 4alpha-PMA - J61099 - Alfa Aesar

J61099 4alpha-Phorbol 12-myristate 13-acetate, 99%

Numéro CAS
63597-44-4
Synonymes
4alpha-PMA

Dimensions Prix ($) Quantité Disponibilité
1mg 160,00
5mg 540,00
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4alpha-Phorbol 12-myristate 13-acetate, 99%

MDL
MFCD00153860

Propriétés chimiques

Formule
C36H56O8
Poids formulaire
616.83
Forme
Powder or film
Sensibilité
Light Sensitive
Solubilité
Soluble in DMSO, methanol or ethanol. Dilute stock solution into aqueous medium at final concentrations of ~2-5µM

Applications

4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

Notes

Light sensitive. Incompatible with oxidizing agents and heat.

Références bibliographiques

R.A.Nichols; J.W.Haycock; J.K.Wang; P.Greengard. Phorbol ester enhancement of neurotransmitter release from rat brain synaptosomes. Journal of Neurochemistry. 1987, 48,(2), 615-621.

 

S.M.Fischer; K.E.Patrick; M.L.Lee; G.S.Cameron. 4 Beta- and 4 alpha-12-O-tetradecanoylphorbol-13-acetate elicit arachidonate release from epidermal cells through different mechanisms. Cancer Research. 1991, 51,(3), 850-856.

Mentions de danger et de prudence du SGH

Mentions de prudence: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,7332
Code tarifaire harmonisé
2915.90
TSCA
No

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Consulté récemment

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Analytique et matériel de laboratoire