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109511-58-2 - U0126, 99+% - 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene - J61246 - Alfa Aesar

J61246 U0126, 99+%

Numéro CAS

Dimensions Prix ($) Quantité Disponibilité
25mg 167,00
100mg 300,00
300mg 624,00
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U0126, 99+%


Propriétés chimiques

Poids formulaire
Soluble in DMSO. Poorly soluble in ethanol and water


U0126, is used as a selective MAP Kinase Kinase (MKK, MEK) inhibitor. U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.


U0126 is hygroscopic and photosensitive. Store in a tightly sealed vial and protect from light. Store at -20?C. Solid product is stable 1 year at -20°C.

Références bibliographiques

Duncia et al. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.. Bioorg.Med.Chem.Lett. 1998, 8,(20), 2839-44.

Favata et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J.Biol.Chem. 1998, 273,(29), 18623-32.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé


  • A15180

    (1-Hexadecyl)triphenylphosphonium bromide, 98+%
  • J63370

    Cinanserin hydrochloride, 99+%
  • 13546

    Tin single crystal disc, 10mm (0.39in) dia, 1-3mm (0.04-0.1in) thick, (100) orientation, ±0.5°
  • L19413

    (R)-(+)-N-Methoxymethyl-N-(trimethylsilyl)methyl-1-phenylethylamine, tech. 85%
  • A11437

    Dimethyl acetylenedicarboxylate, 98%

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