6-Azauridine can be applied in antiviral studies. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. It is also used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.
Rada B.; Dragún M. Antiviral action and selectivity of 6-azauridine. Ann N Y Acad Sci. 1977, 284, 410-7.
JM Crance.; N Scaramozzino.; A Jouan.; D Garin. Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flaviviruses. Antiviral research. 2003, 58, (1), 73-79.
Mentions de danger (UE): H302-H312-H332-H351
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Suspected of causing cancer.
Mentions de prudence: P201-P261-P280-P304+P340-P405-P501a
Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.