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32004-67-4 - Sulindac sulfide - J62104 - Alfa Aesar

J62104 Sulindac sulfide

Numéro CAS
32004-67-4
Synonymes

Dimensions Prix ($) Quantité Disponibilité
100mg 247,20
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Sulindac sulfide

MDL
MFCD00869764
EINECS
250-892-2

Propriétés chimiques

Formule
C20H17FO2S
Poids formulaire
340.41
Forme
Powder
Point de fusion
189-191°
Solubilité
Soluble in DMSO

Applications

It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells, and reduces tumor burden in adenomatous polyposis patients. Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Références bibliographiques

S Flis et. al. Antiangiogenic effect of sulindac sulfide could be secondary to induction of apoptosis and cell cycle arrest. Anticancer Research. 2006, 26, ( 4B), 3033-3041.

M T Taylor et. al. Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Research. 2000, 60, ( 23), 6607-6610.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H334-H317-H361-H302

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Suspected of damaging fertility or the unborn child. Harmful if swallowed.

Mentions de prudence: P285-P201-P261-P280-P281-P342+P311-P301+P312-P363-P405-P501a

In case of inadequate ventilation wear respiratory protection. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé
2930.90
TSCA
No
RTECS
NK8236000

Recommandé

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire