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125-84-8 - DL-Aminoglutethimide, 99% - (±)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione - J62182 - Alfa Aesar

J62182 DL-Aminoglutethimide, 99%

Numéro CAS
125-84-8
Synonymes
(±)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione

Dimensions Prix ($) Quantité Disponibilité
1g 34,71
5g 71,92
25g 347,11
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DL-Aminoglutethimide, 99%

MDL
MFCD00010122
EINECS
204-756-4

Propriétés chimiques

Formule
C13H16N2O2
Poids formulaire
232.28
Forme
Powder
Point de fusion
152-154°
Solubilité
Soluble in water (2 mg/ml at 20°C), methanol (50 mg/ml), ethanol (7 mg/ml at 25°C), DMSO (20 mg/ml at 25°C), and chloroform.

Applications

Aminoglutethimide is used to decrease the production of sex hormones and suppress the growth of tumors that need sex hormones to grow. It blocks the production of steroids derived from cholesterol and is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer. It is also a drug of abuse by body builders.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Références bibliographiques

Imming P.; Sinning C.; Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov.2006, 5, (10), 821-34.

Siraki AG.; Bonini MG.; Jiang J.; Ehrenshaft M.; Mason RP. Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol.2007, 20, (7), 1038-45.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,440
Code tarifaire harmonisé
2925.19
TSCA
No
RTECS
MA4026950

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Analytique et matériel de laboratoire