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17230-88-5 - Danazol - 17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole - 2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol - J62200 - Alfa Aesar

J62200 Danazol

Numéro CAS
17230-88-5
Synonymes
17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole
2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol

Dimensions Prix ($) Quantité Disponibilité
100mg 50,16
500mg 217,33
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Danazol

MDL
MFCD00056838
EINECS
241-270-1

Propriétés chimiques

Formule
C22H27NO2
Poids formulaire
337.46
Forme
Powder
Point de fusion
218-220°
Solubilité
Partly soluble in water. Soluble in chloroform (25 mg/ml), acetone, acetonitrile, and ethanol. 17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole and 2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol are the synonym of this compound.

Applications

Danazol is a synthetic gonadotropin inhibitor which has a preventive effect on estrogen -related endometrial carcinogenesis in mice. Danazol therapy has also shown regression of established mammary carcinoma in rats. This medication is used in women to treat pelvic pain and infertility due to a certain uterus disorder (endometriosis) and also to treat breast pain/tenderness/nodules due to a certain breast condition (fibrocystic breast disease). It is also used in both men and women to prevent swelling of the abdomen/arms/legs/face/airway due to a certain congenital disease

Notes

Store at room temperature. Incompatible with oxidizing agents.

Références bibliographiques

Gary G. Liversidge.; Kenneth C. Cundy. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs.Int. J. Pharm. 1995, 125 (1),91-97 .

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H361-H312-H332

Suspected of damaging fertility or the unborn child. Harmful in contact with skin. Harmful if inhaled.

Mentions de prudence: P201-P261-P280-P281-P304+P340-P312-P363-P308+P313-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,2812
Code tarifaire harmonisé
2937.29
TSCA
No
RTECS
TU4157070

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