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59721-29-8 - Camostat methanesulfate, 98% - Camostat mesylate - J62362 - Alfa Aesar

J62362 Camostat methanesulfate, 98%

Numéro CAS
59721-29-8
Synonymes
Camostat mesylate

Dimensions Prix ($) Quantité Disponibilité
25mg 96,12
100mg 264,80
500mg 476,89
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Camostat methanesulfate, 98%

MDL
MFCD00941410

Propriétés chimiques

Formule
C20H22N4O5.CH3SO3H
Poids formulaire
494.52
Forme
Powder
Point de fusion
164-168°
Solubilité
Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).

Applications

It is used as a protease and Trypsin inhibitor. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Références bibliographiques

Horiuchi et al. Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. J.Pharmacol.Exp.Ther. 1990, 252(1), 320-6.

Ishikura et al. The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 2007, 80(21), 1999-2004.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H400-H315-H319-H335-H303

Very toxic to aquatic life. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May be harmful if swallowed.

Mentions de prudence: P261-P273-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,1728
Classe de danger
9
Groupe d'emballage
III
Code tarifaire harmonisé
2925.29
TSCA
No
RTECS
CY1571620

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Catalyseurs

Analytique et matériel de laboratoire