Consentement d'utilisation des Cookies

J'accepte. Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

52665-69-7 - Antibiotic A23187, 98% - Calcimycin - Calcium ionophore A23187 - J63020 - Alfa Aesar

J63020 Antibiotic A23187, 98%

Numéro de CAS
52665-69-7
Synonymes
Calcimycin
Calcium ionophore A23187

Conditionnement Prix ($) Quantité Disponibilité
10mg 131,00
Ajouter au panier Ajouter au devis en vrac Afficher l'article

Antibiotic A23187, 98%

MDL
MFCD00151202
EINECS
258-084-1

Propriétés chimiques

Formule
C29H37N3O6
Poids moleculaire
523.62
Forme
Powder
Solubilité
Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate

Applications

A23187 (Mixed Calcium-Magnesium Salt) is used in cell activation experiments when calcium dose-response data are not required. Ca-Mg ratio ~ 1:1. it is widely used as a compound in cell activation. It is used as a highly selective Ca2+ ionophore. it is used in studies of intracellular Ca2+ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation. A23187 is a widely used ionophore. It has the ability to increase the intracellular concentrations of cations and is widely used to increase the intracellular levels of calcium. Visualization of Synaptic Ca2+ Calmodulin-Dependent Protein Kinase II Activity in Living Neurons.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.

Références bibliographiques

Ding et al. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem.2007, 282, (7), 4702-10 .

Kajitani et al. Mechanism of A23187-induced apoptosis in HL-60 cells: dependency on mitochondrial permeability transition but not NADPH oxidase. Biosci.Biotechnol.Bichem.2007, 22, (4), 888-93.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,1639
Beilstein
1096801
Code tarifaire harmonisé
2941.90
TSCA
No
RTECS
DM4676000

Recommandé

  • A12616

    Pyrrole, 98+%
  • A17320

    1-Nitro-2-(n-octyloxy)benzene, 98%
  • 22909

    Methanol, ultrapure, HPLC Grade, 99.8+%
  • 41688

    Poly(styrene sulfonic acid) sodium salt, M.W. 70,000
  • H56533

    3,4-Ethylenedioxythiophene, 97%

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire