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59-05-2 - Methotrexate - J63075 - Alfa Aesar

J63075 Methotrexate

Numéro de CAS
59-05-2
Synonymes

Conditionnement Prix ($) Quantité Disponibilité
100mg 112,00
1g 571,00
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Methotrexate

MDL
MFCD00150847
EINECS
200-413-8

Propriétés chimiques

Formule
C20H22N8O5
Poids moleculaire
454.44
Forme
Powder
Sensibilité
Light Sensitive & Hygroscopic
Solubilité
Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.

Applications

Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis (RA) and other inflammatory types of arthritis. It is used as an anticancer drug.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents. Protect from light

Références bibliographiques

Allegra et al. Evidence for direct inhibition of de novo protein synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate. J.Biol.Chem. 1987, 262, (28), 13520-6.

Cronstein, B. N. Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis. Pharmacological Reviews . 2005, 57, (2), 163-172.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H301-H315-H319-H360

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May damage fertility or the unborn child.

Mentions de prudence: P201-P280-P301+P310a-P305+P351+P338-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,5985
Classe de danger
6.1
Groupe d'emballage
III
Code tarifaire harmonisé
2933.59
TSCA
Yes
RTECS
MA1225000

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