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10540-29-1 - Tamoxifen, 98% - cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene - J63509 - Alfa Aesar

J63509 Tamoxifen, 98%

Numéro CAS
10540-29-1
Synonymes
cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene

Dimensions Prix ($) Quantité Disponibilité
500mg 84,50
1g 143,00
5g 632,00
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Tamoxifen, 98%

MDL
MFCD00010454
EINECS
234-118-0

Propriétés chimiques

Formule
C26H29NO
Poids formulaire
371.52
Forme
Powder
Solubilité
Insoluble in water. Soluble in methanol, ethanol, propanol or propylene glycol.Soluble in dimethyl sulfoxide, dichloromethane and ethanol. Insoluble in water.

Applications

Inhibitor of protein kinase C and induces apoptosis in cancer cells Tamoxifen is used in the treatment of both early and advanced estrogen receptor positive breast cancer in pre- and post-menopausal women. It is also used in the treatment of infertility in women with anovulatory disorders as well as to prevent estrogen-related gynecomastia. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.

Notes

Light sensitive. Store in a cool place. Incompatible with strong oxidizing agents.

Références bibliographiques

Mikelman, S.; Guptaroy, B.; Jutkiewicz, E.; Gnegy, M. The Protein Kinase C Inhibitor Tamoxifen Inhibits Neurochemical and Reinforcing Behavioral Effects of Amphetamine. FASEB J. 2015, 29 (1), 930-1011.

Chlebowski, R. T. IBIS-I tamoxifen update: maturity brings questions. Lancet Oncol. 2015, 16 (1), 7-9.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H350-H360-H362

May cause cancer. May damage fertility or the unborn child. May cause harm to breast-fed children.

Mentions de prudence: P263-P260-P201-P281-P264-P270-P202-P308+P313-P405-P501a

Avoid contact during pregnancy/while nursing. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,9048
Code tarifaire harmonisé
2922.29
TSCA
No
RTECS
KR5919600

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Analytique et matériel de laboratoire