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J63983 Wortmannin, Penicillium funiculosum, 99+%

Numéro de CAS
19545-26-7
Synonymes
KY 12420

Stock No. Conditionnement Prix ($) Quantité Disponibilité
J63983-MA 10mg 118,00
J63983-MB 25mg 255,00
J63983-MF 50mg 474,00
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Wortmannin, Penicillium funiculosum, 99+%

MDL
MFCD00133927

Propriétés chimiques

Formule
C23H24O8
Poids moleculaire
428.44
Forme
Powder
Storage & Sensitivity
Store at -20°C. Light Sensitive.
Solubilité
Soluble in DMSO, ethanol, methanol, and DMF.

Applications

Wortmannin is used as inhibitor of phosphatidylinositol 3-kinase, used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.

Notes

Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Références bibliographiques

Mantle, P.G. Secondary Metabolites of Penicillium and Acremonium. Penicillium and Acremonium. 1987, 1, 161-243.

Walter Haefliger.; Daniel Hauser. Isolierung und Strukturaufklärung von 11-Desacetoxy-wortmannin. Helvetica Chimica Acta. 1973, 56, (8), 2901-2904.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H300-H310-H330

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.

Mentions de prudence: P260-P262-P264b-P270-P271-P280-P284-P301+P310-P302+P350-P304+P340-P310-P330-P361-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Do not get in eyes, on skin, or on clothing. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Gently wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Rinse mouth. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Autres références

Merck
14,10053
Beilstein
67676
Classe de danger
6.1
Groupe d'emballage
I
Code tarifaire harmonisé
2932.20
TSCA
No
RTECS
CB9641000

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Catalyseurs

Analytique et matériel de laboratoire