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67-73-2 - Fluocinolone acetonide - 6-alpha-Fluorotriamcinolone acetonide - J63996 - Alfa Aesar

J63996 Fluocinolone acetonide

Numéro CAS
67-73-2
Synonymes
6-alpha-Fluorotriamcinolone acetonide

Dimensions Prix ($) Quantité Disponibilité
100mg 27,97
1g 124,00
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Fluocinolone acetonide

MDL
MFCD00010525
EINECS
200-668-5

Propriétés chimiques

Formule
C24H30F2O6
Poids formulaire
452.49
Forme
Crystalline powder
Point de fusion
267-269°
Solubilité
Soluble in water (partly), DMSO, alcohol, chloroform and methanol.

Applications

Fluocinolone acetonide is primarily used in dermatology to reduce skin inflammation and relieve itching. It acts as an inhibitor of tumor cells and it can regulate lipid metabolism by modulating gene expression. It can also inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, it can inhibit TNF-α angiogenesis.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Références bibliographiques

Glenn J.Jaffe, MD; Joshua Ben-nun, MD; Hong Guo, PhD; James P.Dunn, MD; Paul Ashton, PhD. Fluocinolone acetonide sustained drug delivery device to treat severe uveitis. Ophthalmology. 2000, 107,(11), 2024-2033.

 

B.J.Poulsen; E.Young; V.Coquilla; M.Katz. Effect of topical vehicle composition on the in vitro release of fluocinolone acetonide and its acetate ester. Journal of Pharmaceutical Sciences. 1968, 57,(6), 928-933.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,4150
Code tarifaire harmonisé
2937.22
TSCA
No
RTECS
TU3830000

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