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2627-69-2 - 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98% - Acadesine - AICAR - J64720 - Alfa Aesar

J64720 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98%

Numéro CAS
2627-69-2
Synonymes
Acadesine
AICAR

Dimensions Prix ($) Quantité Disponibilité
50mg 112,50
200mg 290,77
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5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98%

MDL
MFCD00869751
EINECS
220-097-5

Propriétés chimiques

Formule
C9H14N4O5
Poids formulaire
258.23
Forme
Powder
Point de fusion
214-215°
Solubilité
Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml

Applications

5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

Notes

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Références bibliographiques

Lee A. Witters. The blooming of the French lilac. J Clin Invest. 2001, 108, (8), 1105-1107.

Yu, X.; McCorkle, S.; Wang, M.; Lee, Y.; Li, J.; Saha, A.K.; Unger, R.H.; Ruderman, N.B. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia. 2004, 47, (11), 2012-2021.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,16
Code tarifaire harmonisé
2934.99
TSCA
Yes

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Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire