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Acetylene-PEG4-maleimide - 3-(N-maleimidyl)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)propionamide - J64859 - Alfa Aesar

J64859 Acetylene-PEG4-maleimide

Numéro CAS
Synonymes
3-(N-maleimidyl)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)propionamide

Dimensions Prix ($) Quantité Disponibilité
25mg 105,00
100mg 225,70
500mg 840,00
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Acetylene-PEG4-maleimide

MDL
MFCD22380740

Propriétés chimiques

Formule
C18H26N2O7
Poids formulaire
382.41
Forme
Viscous liquid or solid
Solubilité
Soluble in water.

Applications

Heterobifunctional cross linker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character. A bifunctional linker with sulfhydryl reactive and azide reactive groups. Contains a PEG spacer to increase solubility

Notes

Keep container tightly closed. Store away from oxidizing agents.

Références bibliographiques

Hao Jiang.; Tianqing Zheng.; Aime Lopez-Aguilar.; Lei Feng.; Felix Kopp.; Florence L. Marlow.; Peng Wu. Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem. 2014, 25, (4), 698-706.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé
2925.29
TSCA
No

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Catalyseurs

Analytique et matériel de laboratoire