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J65154 9-beta-D-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate, 99%

Numéro de CAS
Fludarabine monophosophate

Stock No. Conditionnement Prix ($) Quantité Disponibilité
J65154-MD 250mg 34,80
J65154-03 1g 125,00
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9-beta-D-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate, 99%


Propriétés chimiques

Poids moleculaire
Storage & Sensitivity
Keep Cold.
Soluble in DMSO or water at 5mg/ml


A chemotherapy drug used in the treatment of hematological malignancies. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase-?, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.


Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat. Store in refrigerator.

Références bibliographiques

L E Robertson; M J Keating. Fludarabine phosphate in the treatment of chronic lymphocytic leukemia: biology, clinical impact, and future directions. Cancer treatment and research. 1993, 64, 105-119.

W Plunkett; P Huang; V Gandhi. Metabolism and action of fludarabine phosphate. Seminars in Oncology. 1990, 17, (5 Suppl 8), 3-17.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Autres références

Code tarifaire harmonisé


Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux


Analytique et matériel de laboratoire