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443797-96-4 - Aurora Kinase/Cdk Inhibitor - 4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide - J65997 - Alfa Aesar

J65997 Aurora Kinase/Cdk Inhibitor

Numéro de CAS
443797-96-4
Synonymes
4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide

Conditionnement Prix ($) Quantité Disponibilité
5mg 377,00
Ajouter au panier Ajouter au devis en vrac Afficher l'article

Aurora Kinase/Cdk Inhibitor

MDL
MFCD11100270

Propriétés chimiques

Formule
C15H12F2N6O3S.CH3CN
Poids moleculaire
435.41
Forme
Powder
Sensibilité
Light Sensitive
Solubilité
Soluble in DMSO at 15mg/ml

Applications

Aurora Kinase/Cdk Inhibitor is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. It as been shown to induce growth suppression and mitotic defects, these results suggest that Aurora Kinase/Cdk Inhibitor could be useful for cell cycle analysis and therapy of various cancers, including Ewing's sarcoma.

Notes

Light Sensitive, store in dark. Keep the container tightly closed. Store away from oxidizing agent. Store under dry inert gas.

Références bibliographiques

Emanuel, S.et al. The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases. Cancer Res., 2005,65(19), 9038-9046.

Lin, R. et al. 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem., 2005,48(13), 4208-11.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé
3504.00
TSCA
No

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Consulté récemment

Produits chimiques

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Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire