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87239-81-4 - Cefpodoxime proxetil, 96% - J66061 - Alfa Aesar

J66061 Cefpodoxime proxetil, 96%

Numéro de CAS
87239-81-4
Synonymes

Conditionnement Prix ($) Quantité Disponibilité
1g 241,00
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Cefpodoxime proxetil, 96%

MDL
MFCD00865088

Propriétés chimiques

Formule
C21H27N5O9S2
Poids moleculaire
557.60
Forme
Powder
Point de fusion
111-113°
Sensibilité
Light Sensitive
Solubilité
Soluble in DMSO

Applications

A broad spectrum antibiotic. Cefpodoxime proxetil is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Product is to be used for research and development only.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.

Cefpodoxime proxetil is a broad spectrum antibiotic which targets a wide variety of gram positive and gram negative bacteria especially those which cause otitis media and pharyngitis.

Références bibliographiques

Georgopapadakou, N. H. Mechanisms of Action of Cephalosporin 3'- quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli. American Society for Microbiology 1992, 37.3, 559-565.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H334-H317

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.

Mentions de prudence: P260-P201-P280g-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé
2941.90
TSCA
No
RTECS
XI0367370

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Consulté récemment

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Catalyseurs

Analytique et matériel de laboratoire