2,3-O-Isopropylidene-D-ribonic acid-1,4-lactone is used for the synthesis of C-nucleosides, prostanoids and GABA analogs via homochiral 2-piperidones. It is the starting material for the preparation of biochemical compounds including C-nucleosides, such as neplanocin A, and GABA analogs, via homochiral 2-piperidones.
Kotohiro Nomura and Richard R. Schrock.Preparation of Sugar-Coated Homopolymers and Multiblock ROMP Copolymers. Macromolecules.1996, 29, (2), 540-545.
Amélia P. Rauter; José Figueiredo; Maria Ismael; Tana Canda; Josep Font; Marta Figueredo. Efficient synthesis of α,β-unsaturated γ-lactones linked to sugars. Tetrahedron: Asymmetry.2001, 12, 1131-1146.