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Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is also used in organic synthesis as a source for CCl2. In the swine tracheal smooth muscle, chloroform has been demonstrated to directly and in a concentration dependent manner induce contractions. It has been observed that Chloroform can release Ca2+ from ryanodine sensitive receptors in chloroform-induced contraction in swine tracheal smooth muscle. At concentrations of 100 and 250 ppm in mouse splenocyte, basal proliferation was increased yet a decrease in circulating neutrophils was documented.
Auttachoat W, et al. Immunotoxicological profile of chloroform in female B6C3F1 mice when administered in drinking water.Drug Chem. Toxicol.,2009,32(1), 77-87.
Lin YR, et al. Role of ryanodine receptors in chloroform-induced contraction in Swine tracheal smooth muscle.Toxicol Appl Pharmacol.,2002,183(2), 146-51.
Mentions de danger (UE): H302-H315-H319-H331-H335-H336-H351-H361d-H373
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Toxic if inhaled. May cause respiratory irritation. May cause drowsiness or dizziness. Suspected of causing cancer. Suspected of damaging the unborn child. May cause damage to organs through prolonged or repeated exposure.
Mentions de prudence: P201-P202-P260-P264b-P270-P271-P280i-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P337+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant