Consentement d'utilisation des Cookies

J'accepte Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

129-56-6 - SP600125, 99% - 1,9-Pyrazoloanthrone - J67272 - Alfa Aesar

J67272 SP600125, 99%

Numéro CAS

Dimensions Prix ($) Quantité Disponibilité
50mg 86,80
100mg 144,00
Ajouter au panier Ajouter au devis en vrac Afficher l'article

SP600125, 99%


Propriétés chimiques

Poids formulaire
Soluble in DMSO at approx. 20mg/ml


SP 600125 is a potent and reversible inhibitor of JNK1-3 with an IC50 value of 0.11 ?M.1 It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells. SP 600125 also prevents apoptosis in many cell types, including B-cells, and inhibits autophagy in HeLa cells. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 ?M). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Prevents BMP9-induced osteogenic differentiation of MSCs.


Store away from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store in freezer at -20°C.

Références bibliographiques

Bennett, B.L, et al. SP600125, an anthrapyrazolone inhibitor of jun N-terminal kinase.Proc Natl Acad Sci USA.,2001,98 (24), 13681-13686.

Kim, Y.S., et al. Cross-linking of B7-H1 on EBV-transformed B cells induces apoptosis through reactive oxygen species production, JNK signaling activation, and fasL expression.J Immunol.,2008,1816158-6169.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé


  • L08118

    Methyl 2,5-dichlorothiophene-3-carboxylate, 98%
  • L14137

    (S)-(+)-1,1'-Binaphthyl-2,2'-diyl hydrogen phosphate, 98+%
  • L16986

    Silicon(IV) oxide, powder, 1.0 micron, 99.9%
  • A19336

    3'-Chloro-4'-methylacetanilide, 98%
  • J62195

    PIPES, 1.0M buffer soln., pH 7.0

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux


Analytique et matériel de laboratoire