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55985-85-8 - (2-Carboxyethyl)triphenylphosphonium tribromide, 98+% - L00553 - Alfa Aesar

L00553 (2-Carboxyethyl)triphenylphosphonium tribromide, 98+%

Numéro CAS
55985-85-8
Synonymes

Dimensions Prix ($) Quantité Disponibilité
5g 32,16
25g 132,87
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(2-Carboxyethyl)triphenylphosphonium tribromide, 98+%

MDL
MFCD00051883

Propriétés chimiques

Formule
HO2CCH2CH2P(C6H5)3Br3
Poids formulaire
575.09
Point de fusion
ca 159° dec.
Sensibilité
Moisture Sensitive
Solubilité
It reacts with water. Soluble in THF (25 g/100 mL), dichloromethane, insoluble in alcohol.

Applications

(2-Carboxyethyl)triphenylphosphonium tribromide, is a fine chemical and pharmaceutical intermediate. It is a bromine transfer agent for selective α-bromination of ketones and ketone acetals in the presence of double bonds, activated aromatic rings, esters or another free enolic position.

Notes

Moisture, water Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents, bases. This reagent should be handled in a fume hood.

Références bibliographiques

SP Nikas.; J Grzybowska.; DP Papahatjis. The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model. The AAPS journal. 20046 (4), 23-35.

A Rybár. Annulated Heterocyclo-Purines II: Fused Six-and More-Membered Heterocyclo-Purinediones,-Purinones and-Purineimines. Advances in Heterocyclic Chemistry. 200588 (1), 175-229.

Reagent for ɑ-bromination of ketones. Unsaturated ketones can be selectivelyɑ-brominated in high yield without bromination of the olefinic double bond: Tetrahedron Lett., 373 (1975); Synth. Commun., 19, 1091 (1989). See also 2-Pyrrolidinone hydrotribromide, L00177 for similar reagent.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Mentions de prudence: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
6262851
Classe de danger
8
Groupe d'emballage
II
Code tarifaire harmonisé
2931.90
TSCA
No

Recommandé

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    tert-Butyldimethylchlorosilane, 97%
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    Ethyl chloroacetate, 99%
  • A19302

    (3-Carboxypropyl)triphenylphosphonium bromide, 97%

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire