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4270-27-3 - 6-Chlorouracil, 98+% - 6-Chloro-2,4-dihydroxypyrimidine - 4-Chlorouracil - L01875 - Alfa Aesar

L01875 6-Chlorouracil, 98+%

Numéro CAS
4270-27-3
Synonymes
6-Chloro-2,4-dihydroxypyrimidine
4-Chlorouracil

Dimensions Prix ($) Quantité Disponibilité
1g 47,28
5g 144,20
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6-Chlorouracil, 98+%

MDL
MFCD00014595
EINECS
224-258-0

Propriétés chimiques

Formule
C4H3ClN2O2
Poids formulaire
146.53
Point de fusion
ca 295° dec.
Solubilité
Soluble in Ammonium Hydroxide

Applications

Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Références bibliographiques

Hongdeng Qiu.; Shengxiang Jiang.; Xia Liu. N-Methylimidazolium anion-exchange stationary phase for high-performance liquid chromatography. Journal of Chromatography A. 2006, 1103, (2), 265-270.

Troy Voelke.; Tim Ewell.; Jean Joo.; Eric D. Edstrom. o-Nitrobenzyl as a photocleavable nitrogen protecting group for indoles, benzimidazole, and 6-chlorouracil. Tetrahedron Letters. 1998, 39, (5-6), 359-362.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
120492
Code tarifaire harmonisé
2933.59
TSCA
No

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