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60-31-1 - Acetylcholine chloride, 98+% - 2-Acetoxy-N,N,N-trimethylethanium chloride - 2-Acetyloxy-N,N,N-trimethylethanium chloride - L02168 - Alfa Aesar

L02168 Acetylcholine chloride, 98+%

Numéro CAS
60-31-1
Synonymes
2-Acetoxy-N,N,N-trimethylethanium chloride
2-Acetyloxy-N,N,N-trimethylethanium chloride

Dimensions Prix ($) Quantité Disponibilité
25g 40,99
100g 116,33
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Acetylcholine chloride, 98+%

MDL
MFCD00011698
EINECS
200-468-8

Propriétés chimiques

Formule
CH3CO2CH2CH2N(CH3)3Cl
Poids formulaire
181.66
Point de fusion
149-152°
Sensibilité
Hygroscopic
Solubilité
Soluble in water (600 g/L at 20°C), alcohol, DMSO (36 mg/ml at 25°C), and ethanol (36 mg/ml at 25°C). Insoluble in ether.

Applications

Acetylcholine chloride acts as an endogenous neurotransmitter at cholinergic synapses. The compound has been shown to have ophthalmological uses and can be broken down quickly by choliesterases. Acetylcholine influences many basic cells functions, such as mitosis, cells differentiation, cytoskeletal organization, and cell to cell contact, among other functions. It reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis.The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Notes

Store away from moisture. Store under dry inert gas. Incompatible with heat,oxidizing agents.

Références bibliographiques

John K. Herdklotz; Ronald L. Sass. The crystal structure of acetylcholine chloride: A new conformation for acetylcholine.Biochemical and Biophysical Research Communication.1970, 40 583-588.

Rafael Lorente De Nó. Effects of choline and acetylcholine chloride upon peripheral nerve fibers.Journal of Cellular and Comparative Physiology.1944, 24 85-97.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335-H303

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May be harmful if swallowed.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,87
Beilstein
3571875
Code tarifaire harmonisé
2923.90
TSCA
Yes
RTECS
FZ9800000

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