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19012-03-4 - 1-Methylindole-3-carboxaldehyde, 98+% - 3-Formyl-1-methylindole - L02212 - Alfa Aesar

L02212 1-Methylindole-3-carboxaldehyde, 98+%

Numéro de CAS
19012-03-4
Synonymes
3-Formyl-1-methylindole

Conditionnement Prix ($) Quantité Disponibilité
1g 28,30
5g 80,60
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1-Methylindole-3-carboxaldehyde, 98+%

MDL
MFCD00014570
EINECS
242-750-3

Propriétés chimiques

Formule
C10H9NO
Poids moleculaire
159.19
Point de fusion
67-71°
Sensibilité
Air Sensitive
Solubilité
Insoluble in water.

Applications

1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole).

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. Store under dry inert gas. It is sensitive to air.

Références bibliographiques

Ahmed Abouabdellah.; Robert H. Dodd. A new approach to the synthesis of functionalized pyrido[2,3-b]indoles by way of a palladium-catalyzed ring closing reaction between the N-1 and C-9a positionsn. Tetrahedron Letters. 1998, 31 (15), 2119-2122.

Haiming Zhang.; Richard C Larock. Synthesis of β- and γ-carbolines by the palladium/copper-catalyzed coupling and copper-catalyzed or thermal cyclization of terminal acetylenes. Tetrahedron Letters. 2002, 43(8), 1359-1362.

Autres références

Beilstein
121302
Code tarifaire harmonisé
2933.99
TSCA
No

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Produits chimiques

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Catalyseurs

Analytique et matériel de laboratoire